Wesley Snipes … Blade
Kris Kristofferson … Abraham Whistler
Dominic Purcell … Drake
Jessica Biel … Abigail Whistler
Ryan Reynolds … Hannibal King
Parker Posey … Danica Talos
Mark Berry … Chief Martin Vreede
John Michael Higgins … Dr. Edgar Vance
Callum Keith Rennie … Asher Talos
Paul Levesque … Jarko Grimwood (as Triple H)
Paul Anthony … Wolfe
Françoise Yip … Virago
Michael Rawlins … Wilson Hale (as Michael Anthony Rawlins)
James Remar … Ray Cumberland
Natasha Lyonne … Sommerfield

Director:

David S. Goyer